| Gene Symbol | XRCC1 |
| Aliases | XRCC1PROTEIN |
| Protein Type | Scaffold Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | all tissues: - High expression in brain (neurons, glia) - Moderate expression in other proliferating cells - Induced by oxidative stress - Cell type-s |
| Subcellular Localization | </strong> Nucleus</div> |
| Molecular Weight | 69 kDa |
| Amino Acids | 633 aa |
| Pathways | epigenetic regulation, neurotrophin signaling |
| GeneCards | XRCC1 |
| Human Protein Atlas | XRCC1 |
| XRCC1 Knockout Mice | Embryonic lethal, demonstrating essential role in development. |
| XRCC1 Conditional Knockout Mice | Show neurodegeneration, cancer predisposition, and premature aging. |
| XRCC1 Polymorphic Mice | Display altered DNA repair capacity and disease susceptibility. |
| Associated Diseases | Cancer, Fibrosis |
| Interactions | ALDH1A3, App, BDNF, CAMK2A, CANCER, DNA |
| KG Connections | 57 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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