| Gene Symbol | SYNAPTOTAGMIN1 |
| Aliases | SYNAPTOTAGMIN1 |
| Transmembrane Region (TM) | A single-pass transmembrane domain (residues 1-37) that anchors SYT1 to synaptic vesicles |
| Linker Region (residues 60-90) | A flexible tether connecting the TM domain to the C2 domains |
| C2A Domain (residues 96-259) | The first C2 domain, binds 3 Ca²⁺ ions via highly conserved aspartate residues. The C2A domain interacts with the SNARE complex and phospholipid membranes |
| C2B Domain (residues 271-421) | The second C2 domain, binds 3 Ca²⁺ ions and is essential for synaptic vesicle priming. The C2B domain has polybasic patches that interact with negatively charged phospholipids |
| Cerebral Cortex | Layer 2/3 pyramidal neurons show high SYT1 expression |
| Hippocampus | CA1 pyramidal cells and dentate gyrus granule cells |
| Cerebellum | Parallel fiber-Purkinje cell synapses and climbing fiber-Purkinje cell synapses |
| Brainstem | Auditory brainstem nuclei for fast sound transmission |
| Thalamus | Relay neurons in sensory thalamic nuclei |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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