| Gene Symbol | PRIONPROTEINPRP |
| Aliases | PRIONPROTEINPRP |
| Subcellular Localization | ** | Cell membrane (GPI-anchored), cytoplasm | |
| Alpha-helices | Three alpha-helices (A: 144-154, B: 173-194, C: 200-228) |
| Beta-strands | Two beta-strands (B1: 128-131, B2: 161-164) form a small beta-sheet |
| Glycosylation sites | Two N-linked glycosylation sites (Asn181, Asn197) |
| Copper binding | The octarepeat region binds up to 4 Cu<sup>2+</sup> ions[@brown1997] |
| Beta-sheet content | Increased from ~10% to ~40-50% |
| Protease resistance | C-terminal fragment (residues ~81-231) becomes proteinase K-resistant |
| Aggregation propensity | Forms amyloid fibrils and plaques |
| Glycosylation pattern | Distinct glycoform ratios compared to PrP<sup>C</sup> |
| Antioxidant activity | Copper-bound PrP<sup>C</sup> exhibits SOD-like activity[@brown1997] |
| Cellular stress response | Upregulated under oxidative stress conditions |
| Anti-apoptotic signaling | Activates PI3K/Akt and MAPK pathways |
| Synaptic maintenance | Essential for synaptic structure and function[@colby2011] |
| Neurotransmission | Modulates GABAergic and glutamatergic signaling |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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