| Gene Symbol | PTAU181 |
| Aliases | PTAU181PROTEIN |
| Chromosome | 17q21 |
| GeneCards | PTAU181 |
| Human Protein Atlas | PTAU181 |
| 0N/1N/2N isoforms | Alternative splicing of exon 2 determines N-terminal inserts |
| 3R/4R isoforms | Alternative splicing of exon 10 determines microtubule-binding repeats |
| Phosphorylation sites | Over 85 potential phosphorylation sites on tau |
| Position | Residue 181 in the longest tau isoform (2N4R) |
| Kinases | Primarily phosphorylated by GSK-3β, CDK5, and DYRK1A |
| Phosphatases | PP2A and PP1 dephosphorylate this site under normal conditions |
| Microtubule binding | Tau's repeat domains bind to microtubule surfaces |
| Assembly promotion | Enhances tubulin polymerization into microtubules |
| Axonal transport | Supports fast axonal transport via motor protein interactions |
| Neuronal polarity | Helps maintain axonal identity |
| Associated Diseases | Alzheimer's Disease, CSF, ALS |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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