protein 732 words KG: MITOCHONDRIALCARRIERATA1
Contents

Mitochondrial Carrier ATA-1 Protein

🔬 Protein Info
Gene SymbolMITOCHONDRIALCARRIERATA1
AliasesMITOCHONDRIALCARRIERATA1
Subcellular Localization</th><td>Mitochondrial Inner Membrane</td></tr>
Three Mitochondrial Carrier DomainsEach ~100 amino acids
Six Transmembrane α-HelicesForm the transport channel
Three Internal RepeatsSymmetric three-fold symmetry
PXD motifProline-X-Aspartate in each repeat
Salt bridge networkFor substrate recognition
Ornithine TransportExchanges ornithine with citrulline across the inner membrane
Lysine TransportLow affinity for basic amino acids
Histidine TransportMinor substrate
Urea CycleLinks mitochondrial and cytosolic portions
Amino Acid MetabolismRegulates mitochondrial amino acid pools
Nitric Oxide SynthesisProvides substrate for argininosuccinate synthesis
LiverHigh expression in hepatocytes (urea cycle)
KidneyModerate expression
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (23)

Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36
← Prevpg 2/2

Related Analyses (13)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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