protein 732 words KG: MITOCHONDRIALCARRIERATA1
Contents

Mitochondrial Carrier ATA-1 Protein

🔬 Protein Info
Gene SymbolMITOCHONDRIALCARRIERATA1
AliasesMITOCHONDRIALCARRIERATA1
Subcellular Localization</th><td>Mitochondrial Inner Membrane</td></tr>
Three Mitochondrial Carrier DomainsEach ~100 amino acids
Six Transmembrane α-HelicesForm the transport channel
Three Internal RepeatsSymmetric three-fold symmetry
PXD motifProline-X-Aspartate in each repeat
Salt bridge networkFor substrate recognition
Ornithine TransportExchanges ornithine with citrulline across the inner membrane
Lysine TransportLow affinity for basic amino acids
Histidine TransportMinor substrate
Urea CycleLinks mitochondrial and cytosolic portions
Amino Acid MetabolismRegulates mitochondrial amino acid pools
Nitric Oxide SynthesisProvides substrate for argininosuccinate synthesis
LiverHigh expression in hepatocytes (urea cycle)
KidneyModerate expression
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (23)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.55
Synthetic Biology Approach: Designer Mitochondrial Export Sy
Score: 0.51
Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
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Related Analyses (13)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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