| Gene Symbol | ITPR2 |
| Aliases | ITPR2PROTEIN |
| Function | IP3R2 is one of three mammalian IP3 receptor isoforms |
| Primary Expression | neurons and endocrine cells - Channel Properties: Forms tetrameric channels (~1 |
| Subcellular Localization | </strong></td><td>Endoplasmic Reticulum</td></tr> |
| Molecular Weight | 270 kDa |
| Ensembl ID | ENSG00000123104 |
| GeneCards | ITPR2 |
| Human Protein Atlas | ITPR2 |
| N-terminal ligand-binding domain | The large cytoplasmic domain (approximately 2000 residues) that binds IP3 with high affinity. This domain contains the "IP3-binding core" and is the target for regulatory proteins. |
| Modulatory domain | Located between the binding domain and the transmembrane region, this region contains binding sites for various regulatory proteins including calmodulin and FKBP12. |
| Transmembrane domain | Six hydrophobic segments (M1-M6) that form the ion channel pore. The M1-M4 segments form the voltage sensor-like domain, while M5 and M6 along with the pore loop between them form the channel pore. |
| C-terminal channel domain | Contains the channel pore and regulatory elements including the Ca²⁺ binding site that modulates channel activity. |
| Conductance | Approximately 1 pS under physiological conditions |
| Ion selectivity | Permeable to Ca²⁺, K⁺, and other small cations |
| Associated Diseases | Infection, Parkinson, Viral Infection |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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