| Gene Symbol | ITPR2 |
| Full Name | Inositol 1,4,5-Trisphosphate Receptor Type 2 |
| Function | IP3R2 is one of three mammalian IP3 receptor isoforms |
| Primary Expression | neurons and endocrine cells - Channel Properties: Forms tetrameric channels (~1 |
| Molecular Weight | 270 kDa |
| Ensembl ID | ENSG00000123104 |
| GeneCards | ITPR2 |
| Human Protein Atlas | ITPR2 |
| N-terminal ligand-binding domain | Contains the IP3 binding site and regulatory elements |
| Modulatory domain | Multiple regulatory sites for calcium, ATP, and protein kinases |
| Transmembrane domain | Six membrane-spanning helices forming the ion conductance pore |
| C-terminal channel domain | Forms the Ca²⁺ conducting pore and regulatory tail |
| IP3 | Primary agonist; concentration determines channel open probability |
| Calcium | High cytoplasmic Ca²⁺ can either activate or inhibit depending on concentration |
| ATP | Binding to modulatory sites enhances channel activity |
| Associated Diseases | Infection, Parkinson, Viral Infection |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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