| Gene Symbol | IL |
| Full Name | 6 Protein |
| Function | Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation. |
| GeneCards | IL |
| Human Protein Atlas | IL |
| Classical signaling | Membrane-bound IL-6R + gp130 |
| Trans-signaling | Soluble IL-6R + gp130 (more prevalent in inflammation) |
| IL-6 trans-presentation | Cell-associated IL-6/IL-6R complex engaging gp130 |
| Site I | IL-6R binding (affinity ~ 10^-9 to 10^-10 M) |
| Site II | First gp130 binding |
| Site III | Second gp130 binding (dimeric interface) |
| Associated Diseases | CRC |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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