protein 572 words KG: FERRITINLIGHTPROTEIN
Contents

FTL Protein — Ferritin Light Chain

🔬 Protein Info
Gene SymbolFERRITINLIGHTPROTEIN
AliasesFERRITINLIGHTPROTEIN
Chromosome19q13.12.
Functionimplications for brain disease." Biochim Biophys Acta (2020)](https://pubmed.ncbi.nlm.nih.gov/32092345/))
Molecular Weight~20 kDa per subunit
Length175 amino acids per subunit
Quaternary Structure24-mer (typically 12 H + 12 L chains)
LocationCytosol
Ferroxidase SitePrimarily in heavy chain; light chain provides stability
Hydrophilic ChannelsAllow iron entry into the nanocage
Iron Core BindingLight chain facilitates iron core formation
KG Connections3 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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Related Hypotheses (7)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (8)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (3)

Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: binds
FTL Gene
gene · KG edge: component_of

Knowledge Graph (3 edges)

FTL component_of FERRITINLIGHTPROTEIN
TREM2 binds FERRITINLIGHTPROTEIN
oxidized phosphatidylcholines binds FERRITINLIGHTPROTEIN

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