| Gene Symbol | DYNAMIN1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neurons, where it mediates the final scission of synaptic vesicles from the plasma membrane |
| Molecular Weight | 100 kDa |
| GeneCards | DYNAMIN1 |
| Human Protein Atlas | DYNAMIN1 |
| Human Brain Expression | Searchable expression data across brain regions |
| Cell Type Specificity | Expression patterns in different neuronal populations |
| GTPase domain | N-terminal domain that hydrolyzes GTP to drive membrane fission |
| Middle domain | Mediates dimerization and oligomerization |
| Pleckstrin homology (PH) domain | Binds phosphatidylinositol 4,5-bisphosphate (PIP2) at the neck of clathrin-coated vesicles |
| GTPase effector domain (GED) | Stimulates GTPase activity; functions in self-assembly |
| Synaptic vesicle recycling | Critical for regenerating synaptic vesicles after neurotransmitter release |
| Clathrin-mediated endocytosis | Functions as the mechanical engine for vesicle scission |
| Activity-dependent endocytosis | Dynamin-1 is phosphorylated in a calcium/calmodulin-dependent manner |
| Associated Diseases | neurodegeneration |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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