protein 3,387 words KG: CYTOCHROMECPROTEIN
Contents

Cytochrome c Protein

🔬 Protein Info
Gene SymbolCYTOCHROMEC
AliasesCYTOCHROMECPROTEIN
FunctionThe discovery that cytochrome c functions as both an electron carrier and an apoptosis initiator has profound implications for understanding neurodegeneration.
Subcellular Localization</b></td><td>Mitochondrial intermembrane space</td></tr>
GeneCardsCYTOCHROMEC
Human Protein AtlasCYTOCHROMEC
Ferric form (Fe³⁺)Oxidized state, paramagnetic
Ferrous form (Fe²⁺)Reduced state, diamagnetic
PhosphorylationTyrosine phosphorylation at residue 97 can inhibit apoptosis by preventing cytochrome c release[@ferrer2023]
AcetylationLysine acetylation affects its interaction with apoptotic proteins
NitrosylationS-nitrosylation can modulate its pro-apoptotic activity[@stanimirovic2023]
ATP depletionReduced oxidative phosphorylation capacity
Metabolic stressInability to meet neuronal energy demands[@mattson2023]
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (15)

Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (12)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40

See Also (15)

Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 13 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 13 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 13 hypotheses
Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 13 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 13 hypotheses

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