| Gene Symbol | CHRM2 |
| Full Name | Muscarinic Acetylcholine Receptor M2 |
| Aliases | CHRM2PROTEIN |
| Protein Type | Receptor |
| Function | The Muscarinic Acetylcholine Receptor M2 (CHRM2) is a G protein-coupled receptor (GPCR) that mediates the effects of acetylcholine on slow inhibitory postsynaptic potentials in the heart, smooth muscl |
| Primary Expression | the hippocampus, cerebral cortex, and basal ganglia, where it modulates learning, memory, and r |
| Ensembl ID | ENSG00000131617 |
| GeneCards | CHRM2 |
| Human Protein Atlas | CHRM2 |
| Extracellular N-terminus | Ligand-binding domain for acetylcholine |
| Seven transmembrane helices | Form the ligand-binding pocket |
| Intracellular C-terminus | Couples to G proteins and contains phosphorylation sites |
| [Cortex](/brain-regions/cortex) | Layers II-III, V |
| Basal forebrain | Cholinergic neurons |
| Thalamus | Relay and intralaminar nuclei |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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