| Gene Symbol | ent-gene-28e2cb01 |
| Phosphatidylserine (PS) | Exposed on apoptotic cell membranes |
| Phosphatidylcholine (PC) | Component of cellular membranes and lipoproteins |
| Cholesterol and cholesterol derivatives | Key component of myelin and membrane fragments |
| Oxidized lipids | Generated during oxidative stress and neurodegeneration |
| Lipoprotein particles | Including HDL, LDL, and their derivatives |
| LXR activation | TREM2 signaling activates liver X receptor (LXR) pathway |
| ABCA1/ABCG1 upregulation | Promotes cholesterol efflux to apolipoproteins |
| Prevention of foam cell formation | TREM2-deficient microglia accumulate lipid droplets, becoming foam-like |
| Myelin debris handling | Critical for clearance of cholesterol-rich myelin debris[@chen2024] |
| Lipid accumulation | TREM2-deficient microglia accumulate cytoplasmic lipid droplets |
| LDAM phenotype | Lipid-droplet-associated microglia show enhanced pro-inflammatory signaling |
| Metabolic dysfunction | Lipid accumulation impairs mitochondrial function and cellular energetics |
| Chronically activated state | LDAM cells exhibit sustained inflammatory responses[@wang2024] |
| KG Connections | 94 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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