| Gene Symbol | ent-gene-28e2cb01 |
| Phagocytosis | TREM2 signaling enhances clearance of debris, apoptotic cells, and protein aggregates — critical for maintaining neuronal homeostasis |
| Cytokine regulation | Modulates production of inflammatory cytokines including IL-6, TNF-α, and IL-1β |
| Metabolic adaptation | Supports microglial lipid metabolism, mitochondrial function, and ATP production |
| Cell survival | Provides pro-survival signaling through AKT activation, preventing apoptosis |
| Process extension | Promotes microglial process motility toward sites of injury |
| [Tau](/proteins/mapt-protein) | Hyperphosphorylated tau filaments in Pick's disease and CBD |
| [TDP-43](/proteins/tardbp-protein) | Shared with ALS — critical for understanding TREM2 connections |
| [FUS](/proteins/fus-protein) | Rare FTD cases with FUS inclusions |
| [MAPT](/genes/mapt) | Tau gene mutations cause familial FTD — tau pathology activates microglia |
| [GRN](/genes/grn) | Progranulin gene — lysosomal function, microglial survival |
| [C9orf72](/genes/c9orf72) | Most common genetic cause — regulates lysosomal function |
| [TBK1](/genes/tbk1) | Tau kinase involved in neuroinflammation |
| [VCP](/genes/vcp) | Valosin-containing protein — linked to inclusion body myopathy with FTD |
| [TREM2](/genes/trem2) R47H variant | Associated with increased FTD risk in some cohorts, though less robust than AD |
| [TREM2](/genes/trem2) R62H and D87N | Show nominal association with FTD risk |
| KG Connections | 94 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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