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mechanism 2,674 words KG: ent-gene-694200ea
Contents

GBA Glucocerebrosidase Endolysosomal Pathway in Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-694200ea
Function1. Lysosomal membrane permeabilization: Lipid accumulation destabilizes lysosomal membranes
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (22)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38Circadian-Synchronized Proteostasis Enhancement
Score: 0.74Smartphone-Detected Motor Variability Correction
Score: 0.74Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51Transcriptional Autophagy-Lysosome Coupling
Score: 0.76Noradrenergic-Tau Propagation Blockade
Score: 0.71Autophagosome Maturation Checkpoint Control
Score: 0.71Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65VCP-Mediated Autophagy Enhancement
Score: 0.59Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48APOE-Dependent Autophagy Restoration
Score: 0.88Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Mitochondrial Transfer Pathway Enhancement
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Mitochondrial RNA Granule Rescue Pathway
Score: 0.66The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
pg 1/2Next →

Related Analyses (30)

Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (30)

Proteasome-Ubiquitin System Dysfunction Validation in Parkin
clinical · proposed · Score: 0.40Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40Prodromal Parkinson's Disease Biomarker Development — Early
clinical · proposed · Score: 0.40Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

Knowledge Graph (4 edges)

ent-gene-694200ea data_in benchmark_ot_ad_answer_key:GBA
benchmark_ot_ad_answer_key:GBA data_in ent-gene-694200ea
ent-gene-694200ea participates_in_pathway R-HSA-9840310
ent-gene-694200ea participates_in_pathway R-HSA-390471

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