| Gene Symbol | ent-gene-83d99ff1 |
| N-terminal low-complexity domain (LCD) | Prion-like domain enabling liquid-liquid phase separation |
| RNA recognition motifs (RRMs) | Three RRMs that bind RNA |
| Zinc finger domain | DNA binding capability |
| P525L | Common ALS mutation with severe phenotype |
| R521C/G | Moderate penetrance, typical age of onset |
| R244X | Truncation mutation |
| G156S | Associated with FTD without ALS |
| Autosomal dominant | Most FUS-FTD/ALS mutations show dominant inheritance |
| Variable penetrance | Not all mutation carriers develop disease |
| Anticipation | Earlier onset in subsequent generations (rare) |
| TGFB1 | Alters FUS aggregation propensity |
| RANBP1 | Affects nuclear transport |
| C9orf72 | Can co-occur with FUS mutations 10 |
| Cytoplasmic inclusions | Granular, compact, orskein-like structures |
| Neuronal intranuclear inclusions | Spherical or ring-shaped |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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