| Gene Symbol | ent-gene-257405c9 |
| STING-YY1 Interaction | STING binds to YY1 (Yin Yang 1), a transcription factor, preventing its nuclear translocation |
| LCN2 Upregulation | YY1 sequestration leads to increased transcription of LCN2 (Lipocalin-2) in astrocytes |
| Neurotoxicity | These SASP factors promote neuroinflammation and dopaminergic neuron death |
| IL-6 | Potent pro-inflammatory cytokine that promotes microglial activation and neuronal dysfunction |
| IL-1α/IL-1β | Major drivers of neuroinflammation, activating NF-κB signaling |
| TNF-α | Tumor necrosis factor alpha contributes to excitotoxicity and neuronal death |
| MMP3 | Degrades extracellular matrix proteins and activates pro-IL-1β |
| MMP9 | Involved in blood-brain barrier disruption and leukocyte infiltration |
| CXCL1, CXCL8 | Recruit neutrophils and other immune cells to the brain |
| CCL2/MCP-1 | Monocyte chemoattractant promoting microglial infiltration |
| VEGF | Alters blood-brain barrier permeability |
| PAI-1 | Serpin inhibitor affecting fibrinolysis |
| GRO-α | Pro-inflammatory chemokine |
| Mitochondrial DNA Release | Mitochondrial dysfunction leads to mitochondrial DNA (mtDNA) release into the cytosol, where it can activate cGAS |
| cGAS-Mfn2 Signaling | Studies show metformin can restore mitochondrial function through Mfn2-cGAS signaling, delaying astrocyte senescence |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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