SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
mechanism 2,090 words KG: ent-gene-257405c9
Contents

cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-257405c9
Nuclear envelope dysfunctionLoss of nuclear integrity from tau pathology (AD), α-synuclein (PD), TDP-43 (ALS/FTD), or mHTT (HD) allows nuclear DNA to escape into the cytoplasm[@fang2023].
Micronuclei formationChromosomal instability creates micronuclei whose envelopes rupture, releasing dsDNA that potently activates cGAS. Elevated in ALS and FTD[@xia2022].
Genomic instabilityImpaired DNA repair (known in HD, ALS) causes DNA damage accumulation, generating cytosolic DNA fragments[@wang2024].
KG Connections12 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92CYP46A1 Overexpression Gene Therapy
Score: 0.92SASP-Mediated Complement Cascade Amplification
Score: 0.91Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91Transcriptional Autophagy-Lysosome Coupling
Score: 0.88

Related Analyses (30)

How do dilncRNAs specifically drive molecular crowding and p
neurodegeneration · completedEpigenetic reprogramming in aging neurons
neurodegeneration · completedWhat determines the specificity of DDR protein recruitment t
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Tau Co-Pathology in DLB Clinical Heterogeneity
clinical · proposed · Score: 0.40Genetic Risk Modifiers in DLB Phenotype
clinical · proposed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (12 edges)

h-9f504f5d4d targets ent-gene-257405c9
ent-gene-257405c9 targeted_by h-9f504f5d4d
h-cfcf4d4c0d targets ent-gene-257405c9
ent-gene-257405c9 targeted_by h-cfcf4d4c0d
h-fca0433042 targets ent-gene-257405c9
ent-gene-257405c9 targeted_by h-fca0433042
h-0ac2771e1c targets ent-gene-257405c9
ent-gene-257405c9 targeted_by h-0ac2771e1c
ent-gene-257405c9 data_in benchmark_ot_ad_answer_key:STING
benchmark_ot_ad_answer_key:STING data_in ent-gene-257405c9

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

SciDEX — scidex.ai — Dashboard | Atlas

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)