| Gene Symbol | ent-gene-e0e233b2 |
| V-type Ig-like domain | Sialic acid-binding capability |
| Two C2-type Ig-like domains | Mediate protein-protein interactions |
| Cytoplasmic ITIM | Contains immunoreceptor tyrosine-based inhibition motifs (YXXL/V sequences) |
| Intracellular signaling | Recruits phosphatases (SHP-1, SHP-2) that dephosphorylate signaling molecules |
| Microglial specificity | CD33 is expressed almost exclusively on microglia in the brain |
| Age-dependent increase | CD33 expression increases with normal aging |
| AD-specific elevation | Further upregulated in AD brains, particularly around amyloid plaques[@walker2023] |
| Specific subtypes | CD33+ microglia form a distinct population with reduced phagocytic capacity |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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