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mechanism 1,880 words KG: ent-gene-8c4c3123
Contents

Brain-Derived Neurotrophic Factor in Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-8c4c3123
PrecursorPre-proBDNF (32 kDa)
Mature formmBDNF (14 kDa)
Alternative splicingMultiple BDNF transcripts with distinct distribution
ApoptosisWhen bound by pro-BDNF
SurvivalWhen co-expressed with TrkB
Synaptic plasticityThrough NF-κB activation
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (146)

Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74Epigenetic Memory Erasure via TET2 Activation
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74Aquaporin-4 Polarization Rescue
Score: 0.73Senescence-Associated Myelin Lipid Remodeling
Score: 0.73Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73CYP46A1 Overexpression Gene Therapy
Score: 0.73Adenosine-Astrocyte Metabolic Reset
Score: 0.73Phase-Separated Organelle Targeting
Score: 0.73Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72Retinal Vascular Microcirculation Rescue
Score: 0.72
← Prevpg 2/8Next →

Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (10 edges)

biomarkers-bdnf-brain-derived-neurotrophic-factor describes ent-gene-8c4c3123
ent-gene-8c4c3123 data_in benchmark_ot_ad_answer_key:BDNF
benchmark_ot_ad_answer_key:BDNF data_in ent-gene-8c4c3123
15518235 has central roles in ent-gene-8c4c3123
15518235 appears essential to ent-gene-8c4c3123
15518235 modification of ent-gene-8c4c3123
21768599 may mediate ent-gene-8c4c3123
41104344 elevated ent-gene-8c4c3123
30642045 plays no role in ent-gene-8c4c3123
40133606 plays a role in ent-gene-8c4c3123

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