SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
mechanism 1,880 words KG: ent-gene-8c4c3123
Contents

Brain-Derived Neurotrophic Factor in Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-8c4c3123
PrecursorPre-proBDNF (32 kDa)
Mature formmBDNF (14 kDa)
Alternative splicingMultiple BDNF transcripts with distinct distribution
ApoptosisWhen bound by pro-BDNF
SurvivalWhen co-expressed with TrkB
Synaptic plasticityThrough NF-κB activation
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

Wikipedia

Related Hypotheses (146)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Purinergic Signaling Polarization Control
Score: 0.71Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71Noradrenergic-Tau Propagation Blockade
Score: 0.71HDAC3-Selective Inhibition for Clock Reset
Score: 0.71Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71Autophagosome Maturation Checkpoint Control
Score: 0.71Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71Membrane Cholesterol Gradient Modulators
Score: 0.71Orexin-Microglia Modulation Therapy
Score: 0.71TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71Lysosomal Enzyme Trafficking Correction
Score: 0.71Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Microglial Purinergic Reprogramming
Score: 0.70SASP-Mediated Complement Cascade Amplification
Score: 0.70Mechanosensitive Ion Channel Reprogramming
Score: 0.70
← Prevpg 3/8Next →

Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (10 edges)

biomarkers-bdnf-brain-derived-neurotrophic-factor describes ent-gene-8c4c3123
ent-gene-8c4c3123 data_in benchmark_ot_ad_answer_key:BDNF
benchmark_ot_ad_answer_key:BDNF data_in ent-gene-8c4c3123
15518235 has central roles in ent-gene-8c4c3123
15518235 appears essential to ent-gene-8c4c3123
15518235 modification of ent-gene-8c4c3123
21768599 may mediate ent-gene-8c4c3123
41104344 elevated ent-gene-8c4c3123
30642045 plays no role in ent-gene-8c4c3123
40133606 plays a role in ent-gene-8c4c3123

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.
SciDEX — scidex.ai — Dashboard | Atlas