| Gene Symbol | WASHC1 |
| Full Name | WASH Complex Subunit 1 |
| Chromosome | 9 |
| Function | WASH complex subunit 1 (WASHC1) is a critical component of the WASH (Wiskott-Aldrich syndrome protein and SCAR homologue) complex, which regulates actin polymerization and endosomal trafficking. |
| Ensembl ID | ENSG00000197746 |
| GeneCards | WASHC1 |
| Human Protein Atlas | WASHC1 |
| Endosomal transport | The WASH complex regulates retrograde transport from early endosomes to the trans-Golgi network (TGN) |
| Autophagosome formation | WASHC1 is involved in autophagy through its role in endosomal trafficking and cargo sorting[@phillipskrawczak2021] |
| Dendritic spine morphogenesis | In neurons, WASHC1 localizes to dendritic compartments and regulates spine development through actin cytoskeleton remodeling |
| Brain | Cerebral cortex, hippocampus, basal ganglia, and cerebellum |
| High expression in neurons | Particularly in dendritic arborizations and growth cones |
| Cellular localization | Primarily endosomal membranes, with enrichment in early endosomes and recycling endosomes |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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