| Gene Symbol | TUBA1A |
| Full Name | Tubulin Alpha 1A |
| Chromosome | 12q13.12 |
| Protein Type | Gene |
| Function | is a gene located on chromosome 12q13. |
| Primary Expression | neurons of the developing and adult central nervous system |
| Molecular Weight | 50 kDa |
| Amino Acids | 450 aa |
| Exons | 5 |
| GeneCards | TUBA1A |
| Human Protein Atlas | TUBA1A |
| N-terminal GTP-binding domain | Contains the exchangeable GTP site (N-site) that binds GTP, which is hydrolyzed to GDP during microtubule polymerization. This domain is critical for tubulin dimer formation and microtubule dynamics. |
| Intermediate domain | Variable region that determines isoform-specific properties and is the site of post-translational modifications. |
| C-terminal tail | Contains the binding site for microtubule-associated proteins (MAPs), motor proteins (kinesins and dynein), and the site of polyglutamylation and polyglycylation modifications. |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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