| Gene Symbol | SNX3 |
| Full Name | Sorting Nexin 3 |
| Chromosome | 6q21 |
| Function | SNX3 is a peripheral membrane protein that localizes to early endosomes and functions in several key capacities: |
| UniProt ID | O60443 |
| NCBI Gene ID | 8724 |
| Ensembl ID | ENSG00000128967 |
| OMIM | 604767 |
| GeneCards | SNX3 |
| Human Protein Atlas | SNX3 |
| VPS26/VPS29/VPS35 complex | SNX3 bridges the core retromer complex with cargo proteins |
| Cargo recognition | Mediates selective retrieval of cargo from endosomes to the trans-Golgi network (TGN) or plasma membrane |
| WASH complex interaction | Coordinates with the WASH complex for actin remodeling |
| PI3P binding | Binds specifically to phosphatidylinositol-3-phosphate (PI3P) on early endosomal membranes |
| Membrane targeting | This binding targets SNX3 to endosomal compartments |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease, Neurodegeneration |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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