gene 973 words KG: PSENEN
Contents

PSENEN Gene - Presenilin Enhancer

🧬 Gene Info
Gene SymbolPSENEN
AliasesPage for PSENEN Gene
Chromosome19q13.12
Protein TypeProtease
FunctionPresenilin endoproteolysis — PEN-2 is required for the autocatalytic cleavage of presenilin to generate the active N-terminal and C-terminal fragments
Primary ExpressionBrain (cerebral cortex, hippocampus), Heart, Liver, Lung, Kidney
Amino Acids101 aa
UniProt IDQ9BXG4
NCBI Gene ID55851
Ensembl IDENSG00000105254
OMIM607632
GeneCardsPSENEN
Human Protein AtlasPSENEN
Associated DiseasesAlzheimer's Disease, Familial Alzheimer's Disease
KG Connections2 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 3 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 3 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (2 edges)

PSENEN provides_data_for ds-83b31ef18d49
ds-83b31ef18d49 data_in PSENEN

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