gene 1,317 words KG: PRDM9
Contents

PRDM9

🧬 Gene Info
Gene SymbolPRDM9
Full NamePR/SET Domain 9
Chromosome5p14.2
Protein TypeTransferase
Functionencodes a histone H3 lysine 4 trimethyltransferase with a tandem C2H2 zinc finger array.
Primary Expressiongermline tissues, recent evidence has revealed non-canonical expression in the brain, where it participates in DNA repair, genomic stability maintenan
UniProt IDQ9NQV7
Ensembl IDENSG00000164256
OMIM609760
GeneCardsPRDM9
Human Protein AtlasPRDM9
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Smartphone-Detected Motor Variability Correction
Score: 0.74
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (7)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

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