| Gene Symbol | PDE2A |
| Full Name | Phosphodiesterase 2A |
| Chromosome | 11q13.4 |
| Function | PDE2A is a dual-specificity phosphodiesterase that hydrolyzes both cAMP and cGMP with equal efficiency. |
| Primary Expression | brain and regulates synaptic plasticity, memory, and emotional behavior [^domeklopacinska2016][^epifantseva2019] |
| UniProt ID | [O76074](https://www.uniprot.org/uniprotkb/O76074/entry) |
| GeneCards | PDE2A |
| Human Protein Atlas | PDE2A |
| N-terminal regulatory GAF domain | Binds cGMP to allosterically regulate enzyme activity |
| Associated Diseases | Alzheimer's disease, cardiac function |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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