| Gene Symbol | IL15 |
| Chromosome | 4q31 |
| Protein Type | Cytokine receptor |
| Function | IL-15 is a cytokine with diverse functions in both immune and nervous systems: |
| Primary Expression | neurons, astrocytes, microglia, and oligodendrocytes, where it |
| Molecular Weight | 17 kDa |
| Pathways | PI3K, MAPK, NF-κB |
| NCBI Gene ID | 3600 |
| GeneCards | IL15 |
| Human Protein Atlas | IL15 |
| NK cell development and maintenance | IL-15 is essential for the survival, proliferation, and cytotoxic function of NK cells[@kennedy2000] |
| Memory CD8+ T cell homeostasis | IL-15 supports the maintenance of memory CD8+ T cells independent of antigen[@schluns2000] |
| NKT cell development | Critical for NKT cell development and function |
| Neuroprotection | IL-15 exhibits neuroprotective properties in models of Parkinson's disease and ALS through anti-apoptotic mechanisms[@panga2019] |
| Neuroinflammation | Modulates microglial activation and cytokine production |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
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