| Gene Symbol | GENEEXPRESSIONATLAS |
| Aliases | GENEEXPRESSIONATLAS |
| [APP](/entities/app-protein) | High expression in pyramidal neurons, moderate in interneurons |
| [MAPT](/proteins/tau) (Tau) | High expression in pyramidal neurons; isoform expression shifts in AD |
| [APOE](/proteins/apoe) | Expressed in astrocytes and microglia; APOE4 carriers show altered expression |
| [TREM2](/proteins/trem2) | Microglia-specific expression; expression increases in AD |
| SNCA | High expression in dopaminergic neurons; aggregation triggers cell death |
| GRN | High expression in microglia; progranulin deficiency leads to TDP-43 pathology |
| [C9orf72](/entities/c9orf72) | Moderate neuronal expression; hexanucleotide expansions cause toxicity |
| NEFL, NEFM (Neurofilament) | Released in neurodegeneration; biomarkers |
| CLU (Clusterin) | Astrocyte expression; clearance of debris |
| LRRK2 | Neuronal expression; kinase activity increases in disease |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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