| Gene Symbol | GABBR2 |
| Full Name | Gamma-Aminobutyric Acid Type B Receptor Subunit 2 |
| Chromosome | 9q22.33 |
| Function | encodes the GABA-B2 subunit of the metabotropic GABA receptor |
| Primary Expression | Cerebral cortex, Hippocampus, Thalamus, Cerebellum, Brainstem |
| Amino Acids | 941 aa |
| UniProt ID | O75899 |
| NCBI Gene ID | 9568 |
| Ensembl ID | ENSG00000136928 |
| OMIM | 607340 |
| GeneCards | GABBR2 |
| Human Protein Atlas | GABBR2 |
| G-protein coupling | The heptahelical domain of GABBR2 activates Gi/o heterotrimeric G-proteins upon receptor activation |
| Surface trafficking | Masks the ER retention signal (RSRR motif) on GABBR1, enabling the heterodimer to exit the ER |
| Allosteric modulation | The venus flytrap domain of GABBR2 does not bind GABA but allosterically enhances agonist affinity at GABBR1 |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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