| Gene Symbol | FCGR2A |
| Chromosome | 1q23.3 |
| Protein Type | Receptor |
| Function | FCGR2A encodes a transmembrane glycoprotein receptor that binds the Fc region of IgG antibodies. |
| GeneCards | FCGR2A |
| Human Protein Atlas | FCGR2A |
| Activating isoform | Contains an immunoreceptor tyrosine-based activation motif (ITAM) in the associated FcR γ chain |
| Inhibitory isoform | Contains an immunoreceptor tyrosine-based inhibition motif (ITAM) that can mediate inhibitory signals |
| Phagocytosis | Engulfment of IgG-opsonized particles |
| ADCC | Destruction of antibody-coated target cells |
| Cytokine release | Production of TNF-α, IL-1β, IL-6, and other inflammatory mediators |
| Antigen presentation | Processing and presentation of captured antigens to T cells[@nimmerjahn2008] |
| R131 (high-affinity) | Associated with increased microglial activation and potentially higher AD risk |
| H131 (low-affinity) | May confer protection through reduced chronic inflammation[@huang2017] |
| Chronic neuroinflammation | Persistent microglial activation leading to neuronal damage |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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