gene 1,538 words KG: CLCN9
Contents

CLCN9 — Chloride Voltage-Gated Channel 9

🧬 Gene Info
Gene SymbolCLCN9
Full NameChloride Voltage-Gated Channel 9
Chromosome12q24.31.
Protein TypeChannel
Functionencodes a voltage-gated chloride channel of the CLCN family, located on chromosome 12q24.
Primary Expressionthe proximal tubule and intercalated cells of the collecting duct
Subcellular Localizationintracellular organelles, particularly lysosomes and endosomes. In these compartments, chloride channels like CLC-9 play
Amino Acids800 aa
GeneCardsCLCN9
Human Protein AtlasCLCN9
Associated DiseasesComplex Human Diseases
KG Connections5 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (5 edges)

CLCN9 expressed_in Cell Types
CLCN9 expressed_in Muscle Fibers
CLCN9 associated_with Complex Human Diseases
CLCN9 participates_in Cardiac Repolarization
CLCN9 associated_with Plasma Proteome

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