gene 1,844 words KG: CHCHD5
Contents

CHCHD5 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 5

🧬 Gene Info
Gene SymbolCHCHD5
Full NameCoiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 5
Chromosome2q31.1
Functionis a small mitochondrial protein that plays essential roles in oxidative phosphorylation, cellular respiration, and neuronal survival.
Primary ExpressionMitochondrial (inner membrane/IMS)
Molecular Weight12 kDa
Amino Acids112 aa
UniProt IDQ8N5Z0
NCBI Gene ID130560
Ensembl IDENSG00000182809
GeneCardsCHCHD5
Human Protein AtlasCHCHD5
Twin cysteine motifsCysteine pairs at positions 38-41 and 67-70 form disulfide bonds
Hydrophobic patchesFacilitate membrane association within mitochondria
Potential phosphorylation sitesSerine/threonine residues for regulatory modifications
Associated Diseasesneurodegeneration
KG Connections1 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (1 edges)

genes-chchd5 linked_to CHCHD5

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