| Gene Symbol | ANO2 |
| Full Name | Anoctamin 2 |
| Aliases | Anoctamin 2 (TMEM16B |
| Chromosome | 12p11.23 |
| Protein Type | Channel |
| Function | is a calcium-activated chloride channel (CaCC) member of the anoctamin family (TMEM16). |
| Primary Expression | sensory epithelia including the olfactory epithelium, retina, and hair cells of the inner ear, where it plays critical roles in signal transduction |
| Molecular Weight | 110 kDa |
| GeneCards | ANO2 |
| Human Protein Atlas | ANO2 |
| N-terminal domain | Contains calcium-binding sites [@pifferi2019] |
| Transmembrane helices | 8 TMDs forming the channel pore |
| Intracellular loops | Important for regulation and trafficking |
| Calcium | Primary activator - binds to N-terminal domain [@pifferi2019] |
| Calmodulin | Modulates calcium sensitivity |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!