| Gene Symbol | ADRA2C |
| Full Name | Alpha-2C Adrenergic Receptor |
| Chromosome | 4p16.3 |
| Primary Expression | the central nervous system and peripheral tissues, playing crucial roles in regulating norepinephrine signaling, autonomic function, and stress respon |
| Amino Acids | 462 aa |
| Pathways | MAPK Pathway |
| UniProt ID | [P21917](https://www.uniprot.org/uniprot/P21917) |
| Ensembl ID | ENSG00000141449 |
| GeneCards | ADRA2C |
| Human Protein Atlas | ADRA2C |
| 7 TM Helices (TM1-TM7) | Canonical GPCR structure forming the ligand-binding pocket |
| Disulfide Bond | Conserved cysteine in extracellular loop 2 that stabilizes receptor structure |
| N-linked Glycosylation Sites | N-terminal extracellular domain for proper folding and trafficking |
| Conserved Motifs | DRY motif in TM3 for G protein coupling, NPxxY in TM7 for activation |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
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