| Gene Symbol | ADCY1 |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | **Plasma membrane**: Integral membrane protein with 12 transmembrane domains |
| Molecular Weight | 125 kDa |
| Ensembl ID | ENSG00000164742 |
| GeneCards | ADCY1 |
| Human Protein Atlas | ADCY1 |
| Reaction | ATP → cAMP + PPi (pyrophosphate) |
| Activation | Calcium-calmodulin complex (Ca²⁺-CaM) directly activates AC1 |
| G-protein regulation | Also activated by Gsα subunits from G-protein coupled receptors |
| Regional expression | Highest in hippocampus, cerebral cortex, and cerebellum |
| cAMP dysregulation | Altered cAMP signaling observed in AD brain correlates with cognitive decline |
| Therapeutic targeting | AC1 modulators may enhance cognitive function by boosting cAMP/PKA activity |
| Synaptic dysfunction | Reduced AC1 activity contributes to impaired synaptic plasticity |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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