| Gene Symbol | ATP7BGENE |
| Chromosome | 13q14.3 |
| Subcellular Localization | and protein-protein interactions |
| N-terminal metal-binding domain | Contains six tandem copper-binding repeats (CBD1-CBD6) that sequester excess copper |
| Transmembrane architecture | Eight core transmembrane domains forming the ion-transporting channel |
| P-domain | Catalytic phosphorylation site characteristic of P-type ATPases |
| A-domain | Adenosine nucleotide-binding domain essential for ATP hydrolysis |
| C-terminal tail | Contains targeting signals for subcellular localization and protein-protein interactions |
| Fenton chemistry | Copper participates in the Fenton reaction, converting hydrogen peroxide into highly reactive hydroxyl radicals that damage lipids, proteins, and DNA |
| Lipid peroxidation | Free copper catalyzes peroxidation of polyunsaturated fatty acids in neuronal membranes, compromising membrane integrity and synaptic function |
| Parkinsonian syndrome | Rigidity, bradykinesia, and resting tremor resembling early-onset Parkinson disease |
| Cerebellar ataxia | Intention tremor, dysmetria, and gait instability |
| Dystonia | Involuntary sustained muscle contractions affecting posture and movement |
| Psychiatric features | Depression, personality change, and cognitive decline preceding motor symptoms in approximately 25% of neurological cases |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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