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disease 961 words KG: ent-dise-23473021
Contents

TDP-43 Pathology in Corticobasal Syndrome

Disease Info
Neuronal cytoplasmic inclusionsUbiquitin-positive, TDP-43 positive
Neuronal intranuclear inclusionsLess common but specific
dystrophic neuritesIn affected regions
Limited tau pathologyMay show minimal 4R tau involvement
KG Connections2 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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🌐 Cross-references

OMIMMeSHWikipedia

Related Hypotheses (1)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completedWhat determines the selectivity and efficiency of intercellu
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neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
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neurodegeneration · completed

Related Experiments (24)

cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90TDP-43 mutant mouse model cGAS/STING pathway analysis
validation · proposed · Score: 0.90TDP-43 mitochondrial invasion and DNA release via mPTP
exploratory · proposed · Score: 0.90cGAS/STING pathway validation in TDP-43 mutant mice
validation · proposed · Score: 0.85

Knowledge Graph (2 edges)

h-1f9e65f394 targets ent-dise-23473021
ent-dise-23473021 targeted_by h-1f9e65f394

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