disease 826 words KG: ent-dise-33d84bdb
Contents

mapt-variants

Disease Info
OMIM157140
InheritanceAutosomal Dominant
Gene SymbolMAPT
Full NameMicrotubule-Associated Protein Tau
Chromosomal Location17q21.31
NCBI Gene ID4137
Ensembl IDENSG00000186868
UniProt IDP10636
Exons16 (major isoform transcripts)
Protein Length352-441 amino acids (6 isoforms)
DatabasesOrphanetClinicalTrialsPubMed

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Related Hypotheses (5)

Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (19)

Plasma ATN biomarkers across AD continuum in Chilean cohort
clinical · proposed · Score: 0.95
Double depletion rescue experiment: tau and MAP6 co-depletio
exploratory · proposed · Score: 0.95
Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90
Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90
Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90

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