disease 927 words KG: Executive Dysfunction in Corticobasal Syndrome
Contents

Executive Dysfunction in Corticobasal Syndrome

Disease Info
Caudate nucleusExecutive selection and sequence planning
Globus pallidusMotor programming and inhibition
ThalamusExecutive attention and working memory gating
Superior longitudinal fasciculusFrontoparietal executive networks
Corpus callosumInterhemispheric executive integration
Frontostriatal loopsCortico-subcortical executive circuits
Increased switch costMarked slowing when transitioning between tasks
PerseverationContinuation of previous response set
Reduced flexibilityInability to adapt to changing demands
Set-loss errorsFailure to maintain task rules
Reduced planning abilityInability to devise multi-step strategies
Poor organizationDifficulty structuring complex activities
KG Connections1 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

No AI portrait yet

Knowledge Graph

Related Hypotheses (26)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Aquaporin-4 Polarization Rescue
Score: 0.73
Retinal Vascular Microcirculation Rescue
Score: 0.72
Noradrenergic-Tau Propagation Blockade
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Microglial Purinergic Reprogramming
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.68
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.67
Sphingolipid Metabolism Reprogramming
Score: 0.66
Glial Glycocalyx Remodeling Therapy
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
pg 1/2Next →

Related Analyses (20)

Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

Knowledge Graph (1 edges)

Executive Dysfunction in Corticobasal Syndrome type_of neurodegenerative_diseases

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)