| Superior parietal lobule hypometabolism | Associated with cortical sensory loss and visuospatial dysfunction |
| Basal ganglia hypometabolism | Particularly in the **putamen** and **globus pallidus** |
| Primary motor cortex sparing | Relative preservation compared to premotor regions, unless disease is advanced[^niethammer2020] |
| Degree of asymmetry | Typically 20-40% difference between hemispheres |
| Clinical correlation | Greater asymmetry correlates with more severe asymmetric motor symptoms |
| Progression | Asymmetry tends to persist but may become more bilateral over time |
| Diagnostic value | High specificity (>85%) for distinguishing CBS from PSP |
| Asymmetric cortical hypoperfusion | Similar pattern to hypometabolism but more sensitive to subtle changes |
| Basal ganglia hypoperfusion | Often more pronounced than metabolic changes |
| Perfusion-motor cortex dissociation | Relative preservation of primary motor cortex perfusion despite motor symptoms[^podgorski2021] |
| Correlation with clinical features | Perfusion deficits correlate with specific symptom profiles |
| KG Connections | 1 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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