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mechanism 3,185 words KG: complement
Contents

Complement-Mediated Synapse Loss

⚙ Mechanism Info
Namecomplement
Related Diseasesdevelopmental synaptic pruning, synaptic pruning
Linked Hypotheses36 hypotheses

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Wikipedia

Related Hypotheses (17)

Selective blockade of classical-pathway activation downstrea
Score: 0.75Excessive C1q/C3/CR3 complement cascade activation initiates
Score: 0.72Microglia and complement sustain post-Aβ neurodegeneration a
Score: 0.69AQP4 Dysregulation Promotes Neuroinflammation Through Impair
Score: 0.68LPS-primed microglial trained immunity establishes persisten
Score: 0.67Microglial TREM2 state determines whether C1q-tagged substra
Score: 0.67Peripheral-Central Immune Decoupling Therapy
Score: 0.66APOE4-microglial complement signaling causes cholinergic-enr
Score: 0.63C1q has spatially distinct functions, with synapse-bound C1q
Score: 0.63Tau fibrils expose neuronal phosphatidylserine and heat-shoc
Score: 0.62Female microglia exhibit heightened complement gene expressi
Score: 0.61Synaptic protection via microglial/complement normalization
Score: 0.56TREM2-complement-amyloid axis as therapeutic target for prot
Score: 0.55Dysregulated microglial glycolysis via HIF1α activation shif
Score: 0.52Complement Cascade Activation Bridges Microglial OxPC Sensin
Score: 0.42Rare TREM2-TYROBP pathway variants complement standard PRS b
Score: 0.38Projection-specific vulnerability to complement-mediated syn
Score: 0.38

Knowledge Graph (6 edges)

complement activates neurotoxicity
biomarkers-complement-c3 describes complement
h-6b9dec7170 targets complement
complement targeted_by h-6b9dec7170
complement regulates synaptic pruning
complement regulates developmental synaptic pruning

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