| Gene Symbol | CLTC |
| Full Name | Clathrin Heavy Chain 1 |
| Chromosome | 17q23.2 |
| Function | Clathrin-mediated endocytosis (CME) is the primary pathway for synaptic vesicle recycling in neurons and for receptor-mediated endocytosis in all cell types. |
| Molecular Weight | 192 kDa |
| Pathways | Inflammasome |
| UniProt ID | [Q00610](https://www.uniprot.org/uniprot/Q00610) |
| Ensembl ID | ENSG00000130224 |
| OMIM | 118955 |
| GeneCards | CLTC |
| Human Protein Atlas | CLTC |
| Core Components | CLTA (clathrin light chain), DNM1/DNM2 (dynamins), Amphiphysin (RBS) |
| Adaptor Proteins | AP2 complex, AP180/CALM, epsin, dynamin |
| Neuronal Function | Synaptic vesicle endocytosis, receptor trafficking, neurotrophin signaling |
| Associated Diseases | neurodegeneration |
| Interactions | Insulin, NLRP3 |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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