| Gene Symbol | ent-gene-e77950cd |
| Substantia nigra pars compacta (SNc) | Dopaminergic neurons — primary site of degeneration in PD |
| Striatum | Medium spiny neurons — receive dopaminergic input |
| Frontal [cortex](/brain-regions/cortex) | Pyramidal neurons — affected in PD dementia |
| Cerebellum | Purkinje cells — motor coordination |
| Constitutive expression | Moderate baseline in adult neurons |
| Stress-induced upregulation | Increased expression under mitochondrial stress |
| Cell-type specificity | Higher expression in metabolically active neurons |
| Cytoplasm | Diffuse cytosolic分布 |
| Mitochondria | Outer membrane recruitment upon mitochondrial damage |
| Synaptic terminals | Presynaptic mitochondria quality control |
| Dendrites | Local mitochondrial maintenance in dendritic branches |
| Nucleus | Transcriptional regulation function |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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