| Gene Symbol | ent-gene-9fbbb105 |
| Function | ### Purinergic Signaling |
| Thalamus | Modulatory roles in thalamocortical circuits |
| Striatum | Involved in basal ganglia signaling pathways |
| [Astrocytes](/entities/astrocytes) | P2Y2 receptors are highly expressed on astrocytes, where they mediate neuroprotective signaling |
| Gq-coupled signaling | Activates phospholipase C (PLC), leading to IP3 production and calcium mobilization from intracellular stores |
| ERK/MAPK pathway | Triggers neuroprotective signaling cascades through MEK/ERK activation |
| PI3K/Akt pathway | Promotes cell survival through Akt phosphorylation |
| Calcium release from ER | IP3-mediated release from endoplasmic reticulum stores |
| Calcium influx | Activation of voltage-gated calcium channels (VGCCs) |
| Calcium waves | Propagation of calcium signals through astrocyte networks |
| Hyperpolarization | Increased K+ conductance in some neuron types |
| Decreased firing rate | Overall inhibitory effect on neuronal excitability |
| Synaptic modulation | Altered GABAergic and glutamatergic transmission |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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