| Gene Symbol | ent-gene-93f521e9 |
| Chromosome | 11 |
| Function | ### Circadian Rhythm Regulation |
| Retina | MTNR1B is expressed in retinal neurons, where it contributes to phototransduction and circadian visual processing. |
| Hypothalamus | MTNR1B neurons in hypothalamic regions regulate metabolic functions and sleep. |
| Pancreatic beta cells | MTNR1B expression in pancreatic islets links melatonin to glucose regulation. |
| Adipose tissue | MTNR1B in adipocytes modulates lipid metabolism and energy balance. |
| MTNR1B gene | Located on chromosome 11, encodes a 362-amino acid GPCR |
| Signal transduction | Couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP levels |
| Ligand affinity | High affinity for melatonin (Kd ~ 10-100 pM) |
| Expression pattern | Species-specific expression patterns in brain and peripheral tissues |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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