| Gene Symbol | ent-gene-8fd2187d |
| N-terminal domain (NTD) | Extracellular domain involved in receptor assembly and allosteric modulation |
| Ligand-binding domain (LBD) | Binds glutamate, the endogenous agonist |
| Transmembrane domain (TM) | Four transmembrane helices that form the ion channel pore |
| C-terminal tail (CTD) | Intracellular domain critical for intracellular signaling and protein interactions |
| Cerebral cortex | Layer 2/3 and Layer 5 pyramidal neurons, GABAergic interneurons |
| Hippocampus | CA1 and CA3 pyramidal neurons, dentate gyrus granule cells |
| Striatum | Medium spiny neurons (MSNs), cholinergic interneurons |
| Thalamus | Relay neurons, reticular nucleus neurons |
| Cerebellum | Purkinje cells, granule cells |
| Amygdala | Principal neurons, interneurons |
| Synaptic targeting | PD (Z domain interactionsGRIP1/GRIP2, PICK1) direct GluA1 to synapses |
| Calcium signaling | Though GluA1/GluA2 receptors are calcium-impermeable, they activate downstream signaling cascades |
| Hippocampal LTP | GluA1 is required for CA1 hippocampal LTP and spatial memory |
| Cortex-dependent learning | Cortical GluA1 expression supports motor learning and texture discrimination |
| Working memory | Prefrontal cortex GluA1 regulates working memory processes |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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