| Gene Symbol | ent-gene-e45e497c |
| Chromosome | 3p21.31 |
| Primary Expression | Highest in microglia, but also detected in neurons of hippocampus, cortex, and spinal cord |
| Molecular Weight | ~40 kDa |
| Gene Location | Chromosome 3p21.31 |
| Protein Length | 355 amino acids |
| Structure | Seven-transmembrane domain typical of GPCRs |
| Ligand | CX3CL1 (fractalkine), a membrane-bound and soluble chemokine |
| Endogenous ligand | CX3CL1 (fractalkine, also called neurotactin) |
| G protein coupling | Gi/Go-coupled, inhibiting adenylate cyclase |
| β-arrestin pathway | Constitutive β-arrestin recruitment |
| Signaling modalities | Both G protein-dependent and independent signaling |
| Microglia to neuron | CX3CL1 release from stressed neurons activates CX3CR1 on microglia |
| Neuron to microglia | CX3CR1 neuron signaling modulates microglial activation state |
| Synaptic surveillance | CX3CR1 neurons receive signals about synaptic health |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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