biomarker 1,972 words KG: ALZHEIMERS
Contents

VILIP-1 and YKL-40 - Alzheimer's Disease Biomarkers

🔬 Protein Info
Gene SymbolVILIP
Full Name1 and YKL-40 as Alzheimer's Disease Biomarkers
AliasesYKL-40, HC-gp39, GP-39
Subcellular Localization**: Cytosolic with some membrane association
GeneCardsVILIP
Human Protein AtlasVILIP
GeneCHI3L1 (Chitinase 3-Like 1)
Protein familyGlycosylhydrolase family 18
Molecular weight~40 kDa
IsoformsMultiple splice variants with tissue-specific expression
StructureChitin-binding domain without catalytic activity
Brain regionsHighest expression in cerebral cortex, hippocampus, and cerebellum
Cell typesPrimarily neuronal (pyramidal neurons, granule cells)
Subcellular localizationCytosolic with some membrane association
Physiological rolesTissue remodeling, inflammation modulation, cell migration
Associated DiseasesALZHEIMER
KG Connections85 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

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Related Hypotheses (26)

Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
← Prevpg 2/2

Related Analyses (18)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

Related Experiments (30)

DLB Treatment Response Biomarkers — Predicting Cholinesteras
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90
Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.51

See Also (15)

Dried Blood Spot Biomarker Test for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Gait Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Digital Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
ASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
EEG Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses

Knowledge Graph (11 edges)

TREM2 associated_with ALZHEIMERS
SERPINA3N associated_with ALZHEIMERS
ALZHEIMERS activates WAM
R47H_TREM2 contributes_to ALZHEIMERS
DAM associated_with ALZHEIMERS
MICROGLIA participates_in ALZHEIMERS
biomarkers-asl-perfusion-alzheimers describes ALZHEIMERS
biomarkers-digital-biomarkers-alzheimers describes ALZHEIMERS
biomarkers-dried-blood-spot-alzheimers describes ALZHEIMERS
biomarkers-fmri-alzheimers describes ALZHEIMERS

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